Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MB_patNAT | 01_NAT716 | France | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDC+ AZT | 21 |
| 2 | AZT+ 3TC | 26 |
| 3 | IDV+ D4T+ 3TC | 34 |
| 4 | SQV+ RTV+ AZT+ 3TC | 47 |
| 5 | SQV+ RTV+ DDI | 74 |
| 6 | NVP+ NFV+ AZT+ 3TC | 26 |
| 7 | NVP+ ABC | 21 |
| 8 | NVP+ LPV+ ABC+ 3TC | 21 |
| 9 | RTV+ DDI+ APV+ 3TC | 24 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | K219R | K103N, Y181C, G190A | V35I, K43Q, E44D, V118I, E169D, H208Y, R211K, K223Q, L228R |
| >01_NAT716| codons 1-244 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEQDGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDIVI CQYVDDLYVASDLEIGQHRTKIEELRQYLWKWGFYTPDRKHQQEPPFRWMGYELHPDKWT VQPI |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54V, V82A, I84V | Q58E | L10I, K14R, K20R, M36I, L63T, I64V, K70T |
| >01_NAT716| codons 1-99 PQITLWQRPIVTIRIGGQLREALLDTGADDTVLEEINLPGRWKPKLIVGIGGFVKVREYD QITVEICGHTAIGTVLVGPTPANVIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Montes, B | Comparison of drug resistance mutations and their interpretation in patients infected with non-B HIV-1 variants and matched patients infected with HIV-1 subtype B. | JAIDS, 2004 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |