Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MB_patMIC C | 02_MICC721 | France | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 26 |
| 2 | AZT+ DDI | 31 |
| 3 | 3TC+ AZT | 18 |
| 4 | AZT+ DDC+ RTV | 10 |
| 5 | AZT+ DDI+ RTV | 21 |
| 6 | 3TC+ D4T+ IDV | 24 |
| 7 | 3TC+ D4T+ SQV | 46 |
| 8 | 3TC+ D4T+ NFV+ NVP | 47 |
| 9 | 3TC+ D4T+ NVP+ RTV+ SQV | 17 |
| 10 | 3TC+ APV+ D4T+ NVP | 17 |
| 11 | APV+ D4T+ DDI+ EFV | 23 |
| 12 | D4T+ DDI+ EFV+ RTV+ SQV | 5 |
| 13 | APV+ D4T+ DDI+ EFV | 16 |
| 14 | D4T+ EFV+ RTV+ SQV | 31 |
| 15 | D4T+ RTV+ SQV | 3 |
| 16 | D4T+ EFV+ RTV+ SQV | 26 |
| 17 | 3TC+ EFV+ RTV | 20 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, I84V, L90M | Q58E | L10I, D60E, I62V, L63P, A71V |
| >02_MICC721| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVREYE QVPIEICGHKVIGTVLVGPTPANVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219R | K103N | E44D, V60I, V118I, K122E, I135T, N175H, K201M | L26F |
| >02_MICC721| codons 1-239 PISPIETVPVKLKPGMDGPKVKQWPFTEEKIKALVEICTELEKDGKISKIGPENPYNTPI FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQHPDIVI YQYVDDLYVGSDLEIGQHRTMIEELRQHLWRWGFYTPDRKHQKEPPFLWMGYELHPDKW |
References
| Author | Title | Citation |
| Montes, B | Comparison of drug resistance mutations and their interpretation in patients infected with non-B HIV-1 variants and matched patients infected with HIV-1 subtype B. | JAIDS, 2004 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |