Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MB_patDOI | 00_DOI704 | France | 1999 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 84 |
| 2 | AZT+DDC | 52 |
| 3 | AZT+DDI | 15 |
| 4 | D4T+DDI | 68 |
| 5 | None | 14 |
| 6 | D4T+DDI+SQV | 15 |
| 7 | 3TC+D4T+SQV | 55 |
| 8 | None | 19 |
| 9 | 3TC+ABC+SQV | 27 |
| 10 | 3TC+ABC+NFV | 14 |
| 11 | 3TC+ABC+IDV+RTV | 29 |
| 12 | 3TC+ABC+AZT+IDV | 36 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G16E, M36I, R41K, I72V |
| >00_DOI704| codons 1-99 PQITLWQRPLVTIKIEGQLKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD QILIEICGHKAVGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75M, M184V, L210W, T215Y | K219E | V35T, E40F, K43E, V60I, V118I, D121H, K122E, I135T, S162A, D177E, Q207E, H208Y, R211K, K223Q, L228H |
| >00_DOI704| codons 1-240 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTFLEEEGKISKIGPENPYNTPI FAIKKKNSTRWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL HEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIGQHRTKIEELREYLWKWGFYTPDEKHQQEPPFHWMGYELHPDKWT |
References
| Author | Title | Citation |
| Montes, B | Comparison of drug resistance mutations and their interpretation in patients infected with non-B HIV-1 variants and matched patients infected with HIV-1 subtype B. | JAIDS, 2004 |