Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| KDR_pat268 | A0372 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT | 72 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, T215Y | V60VI, S68G, D121H, K122E, I135T, K166R, D177E, G196E |
| >A0372| codons 38-244 CTELEKEGKISKIGPENPYNTPIFAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLHEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTRILEPFRKQNPEIVIYQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPI |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15IV, L63Q, I64V |
| >A0372| codons 4-99 TLWQRPLVSIKVGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYDQIQ VEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Kuritzkes, DR | Rate of thymidine analogue resistance mutation accumulation with zidovudine- or stavudine-based regimens. | JAIDS, 2004 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |