Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| KDR_pat242 | A0326 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT | 66 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L33I | G16E, I62IV, L63AP, I93IL | I13IT, K14KHNQ |
| >A0326| codons 4-99 TLWQRPLVTTQIEGQLKEALLDTGADDTVIEEMNLPGRWKPKMIGGIGGFIKVRQYDQVP IEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70KR, M184V | V60VI, R83K, K122AV, T139TIM, K166KR, T200TA, R211K |
| >A0326| codons 38-244 CTEMEKEGKISKIGPENPYNTPIFAIKKKDSTRWRKLVDFRELNKKTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDVDFRKYTAFTIPSINNEMPGIRYQYNVLPQGWKGSP AIFQSSMTRILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRAKIEELRQHLLKWGFTTP DKKHQKEPPFLWMGYELHPDKWTVQPI |
References
| Author | Title | Citation |
| Kuritzkes, DR | Rate of thymidine analogue resistance mutation accumulation with zidovudine- or stavudine-based regimens. | JAIDS, 2004 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |