<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
KDR_pat214 A0286 U.S. 1996 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT+ 3TC 25

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V       E138A, I142V, Q174L, L193M, T200A, R211G D186DY
>A0286| codons 38-244
CTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHP
AGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNATPGVRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKLNPDIVIYQYVDYLYVGSDMEIGQHRAKIEELRQHLLGWGFTTP
DKKHQKEPPFLWMGYELHPDKWTVQPI

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    G17E, R41K, L63P, A71T D25N
>A0286| codons 4-99
TLWQRPLVTIKIGEQLKEALLNTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYDQIP
IEICGHKTIGTVLVGPTPVNIIGRNLLTQIGCTLNF

References
Author Title Citation
Kuritzkes, DR Rate of thymidine analogue resistance mutation accumulation with zidovudine- or stavudine-based regimens. JAIDS, 2004
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005