Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| KDR_pat192 | A0263 | U.S. | 1997 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ D4T | 73 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | T39A, V90VI, K122KR, D123E, I135L, I142S, S162HY, K173R, Q207A, R211K | G152D, W153R |
| >A0263| codons 38-244 CAEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDREFRKYTAFTIPSLNNETPGSRYQYNVLPQDRKGSP AIFQYSMTKILEPFRRQNPDIVIYQYVDDLYVGSDLEIGQHRTKIEELRAHLLKWGFTTP DKKHQKEPPFLWMGYELHPDKWTVQPI |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I15V, K20R, E35D, M36I, R41K, R57K, L63T, E65D, H69HY, I72T, L89M |
| >A0263| codons 4-99 TLWQRPLVTIKVGGQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYDQIT IDICGYKATGTVLVGPTPVNIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Kuritzkes, DR | Rate of thymidine analogue resistance mutation accumulation with zidovudine- or stavudine-based regimens. | JAIDS, 2004 |