Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| KDR_pat143 | A0179 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ D4T | 70 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, M184V | T215C | A98S, E138A, I142IT, S162A, T200A | S68SDGN |
| >A0179| codons 38-244 CTELEKEGKISKIGPENPYNTPVFAIKKKDNTKWRKLVDFRELNKRTQDFWEVQLGIPHP SGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNATPGTRYQYNVLPQGWKGSP AIFQASMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRAKIEELRQHLLRWGFCTP DKKHQKEPPFLWMGYELHPDKWTVQPI |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G17E, Q18I, L19I, M36I, R41K, I62IV, L63P |
| >A0179| codons 4-99 TLWQRPLVTIKIGEIIKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYDQVP IEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Kuritzkes, DR | Rate of thymidine analogue resistance mutation accumulation with zidovudine- or stavudine-based regimens. | JAIDS, 2004 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |