Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| KDR_pat136 | A0163 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT | 89 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M36L, N37S, I62V, L63P, I93L |
| >A0163| codons 7-99 QRPLVTIKIGGQLKEALLDTGADDTVLEELSLPGRWKPKMIGGIGGFIKVRQYDQVPIEI CGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | R83RK, I135V, Q207K, R211A |
| >A0163| codons 38-244 CTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRTKIEELRKHLLAWGFTTP DKKHQKEPPFLWMGYELHPDKWTVQPI |
References
| Author | Title | Citation |
| Kuritzkes, DR | Rate of thymidine analogue resistance mutation accumulation with zidovudine- or stavudine-based regimens. | JAIDS, 2004 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |