<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
KDR_pat72 A0081 U.S. 1996 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 D4T 24

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
Q151M       M41MI, K49R, K122E, I142V, T165I, E169D, Q174K, I178L, T200A, I202V, Q207D, R211K  
>A0081| codons 38-244
CTEIEKEGKISRIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHP
AGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGVRYQYNVLPMGWKGSP
AIFQSSMIKILDPFRKKNPDLVIYQYMDDLYVGSDLEIGQHRAKVEELRDHLLKWGFTTP
DKKHQKEPPFLWMGYELHPDKWTVQPI

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    W6WL, I15IV, L19T, Q61QE, L63P, E65D  
>A0081| codons 4-99
TLLQRPLVTIKVGGQTKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYDEIP
IDICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF

References
Author Title Citation
Kuritzkes, DR Rate of thymidine analogue resistance mutation accumulation with zidovudine- or stavudine-based regimens. JAIDS, 2004
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005