Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| PCF_Pat105 | PCF420 | Italy | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L33I | K14R, M36L, Q61E, L63P, I64V, I93L |
| >PCF420| codons 1-99 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVIEELNLPGRWKPKMIGGIGGFIKVRQYD EIPVEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| I135T, T200I, F214L, A272P, T286A, I293V |
| >PCF420| codons 1-310 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRIKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTEEAE LELAENREIL |
References
| Author | Title | Citation |
| Perno, CF | Impact of mutations conferring reduced susceptibility to lamivudine(3TC) on the response to antiretroviral therapy. | Antivir Ther, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |