Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| PCF_Pat86 | PCF272 | Italy | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| K14KR, G16GE, M36I, R41K, R57K, D60E, L63V, I64V, E65D |
| >PCF272| codons 1-99 PQITLWQRPLVTIRIEGQLKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVKQYE QIVVDICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K49R, I135T, S162C, Q207E, V245M, A272P, I293V |
| >PCF272| codons 1-310 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREIL |
References
| Author | Title | Citation |
| Perno, CF | Impact of mutations conferring reduced susceptibility to lamivudine(3TC) on the response to antiretroviral therapy. | Antivir Ther, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |