Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1599 | CA4554 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC+SQV | 21 |
| 2 | D4T+DDI+SQV | 21 |
| 3 | D4T+DDI+NFV | 21 |
| 4 | NVP+IDV | 26 |
| 5 | D4T+DDI+RTV | 68 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, L210W, T215F | K219E | K103N, Y181C, G190A | K11Q, V35M, T39A, E40F, P55PS, T69N, R83RK, K122E, D123N, R172RK, V179VI, E194D, I195L, T200A, E203X, H208Y, R211RK, K223Q, L228H |
| >CA4554| codons 1-269 PISPIETVPVQLKPGMDGPKVKQWPLTEEKIKALMEICAFLEKEGKISKIGPENSYNTPV FAIKKKNSNRWRKIVDFRELNKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIII CQYMDDLYVASDLDLGQHRAKIXELRQYLWKWGFFTPDEKHQQEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQ |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | G73S | L10I, K20KR, E35D, M36I, N37ND, I62V, L63P, H69K, A71V, V77I |
| >CA4553| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDIDLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGKKVISTVLIGPTPVNIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |