Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ESH_Pat160 | ESH450 | Uganda | 1998 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | 52 |
| 2 | NVP | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K101KE, K103KN, G190GA | V35T, T39M, V60I, D121Y, K122E, E138A, I142AV, K166R, D177E, I178IM, T200X, Q207G, R211K, L228LH, V245K, D250E, A272P, K275N, K277R, L282C, L283I, I293V, L310I |
| >ESH450| codons 1-334 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICMEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKNKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSINNATPGARYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEMVI YQYMDDLYVASDLEIGQHRXKIEELRGHLLKWGFTTPDKKHQKEPPFHWMGYELHPDKWT VQPIKLPEKESWTVNDIQKLVGKLNWASQIYPGINVRQLCKCIRGTKALTEVVPLTEEAE LELAENREIIKEPVHGVYYDPSKDLIAEIQKQGQ |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| R41K, L63LP, I64V, H69Y, I72T |
| >ESH450| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QIPVEICGYKATGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Eshleman, SH | Characterization of nevirapine resistance mutations in women with subtype A vs. D HIV-1 6-8 weeks after single-dose nevirapine. | JAIDS, 2004 |