Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ESH_Pat131 | ESH512 | Uganda | 1998 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | 52 |
| 2 | NVP | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13V, Q18H, M36I, N37NS, R41K, L63C, I64V |
| >ESH512| codons 1-99 PQITLWQRPLVTVKIGGHLKEALLDTGADDTVLEEISLPGKWKPKMIGGIGGFIKVRQYD QICVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M16MT, V35T, K49R, P55PS, V60I, D121Y, K122E, D177E, I178M, T200I, Q207EG, R211K, V245K, D250E, A272P, L282C, T286A |
| >ESH512| codons 1-324 PISPIETVPVKLKPGTDGPKVKQWPLTEEKIKALTEICTEMEKEGKISRIGPENSYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI YQYMDDLYVGSDLEIGQHRIKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIKLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKCLRGAKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKD |
References
| Author | Title | Citation |
| Eshleman, SH | Characterization of nevirapine resistance mutations in women with subtype A vs. D HIV-1 6-8 weeks after single-dose nevirapine. | JAIDS, 2004 |
| Eshleman, SH | Comparison of nevirapine (NVP) resistance in Ugandan women 7 days vs. 6-8 weeks after single-dose nvp prophylaxis: HIVNET 012. | ARHR, 2004 |