Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ESH_Pat22 | ESH45 | Uganda | 1998 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | 52 |
| 2 | NVP | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13V, K14R, E35D, M36L, R41K, R57K, L63P, H69K, L89M |
| >ESH45| codons 1-99 PQITLWQRPLVTVRIGGQLKEALLDTGADDTVLEDLNLPGKWKPKMIGGIGGFIKVKQYD QIPIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, V60I, K122E, D123S, I135T, K173A, Q174K, D177E, V179I, Q207A, R211S, V245MR, D250E, A272T, V276I, T286A, E291D, V292I, I293V, P294T, E312D |
| >ESH45| codons 1-334 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAKNPEIII YQYMDDLYVGSDLEIGQHRTKIEELRAHLLSWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIMLPEKESWTVNDIQKLVGKLNWASQIYTGIKIKQLCKLLRGAKALTDIVTLTEEAE LELAENREILKDPVHGVYYDPSKDLIAEIQKQGQ |
References
| Author | Title | Citation |
| Eshleman, SH | Characterization of nevirapine resistance mutations in women with subtype A vs. D HIV-1 6-8 weeks after single-dose nevirapine. | JAIDS, 2004 |
| Eshleman, SH | Comparison of nevirapine (NVP) resistance in Ugandan women 7 days vs. 6-8 weeks after single-dose nvp prophylaxis: HIVNET 012. | ARHR, 2004 |