Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ESH_Pat16 | ESH253 | Uganda | 1998 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | 52 |
| 2 | NVP | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K11T, K20R, V21I, V35T, T39S, K122E, D123S, K173A, D177E, V179I, T200A, I202V, Q207A, R211S, V245Q, E248DN, D250DE, S251X, T286A, E291D, V292VI, I293V, E312D |
| >ESH253| codons 1-334 PISPIETVPVTLKPGMDGPRIKQWPLTEEKIKALTEICSEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAQNPEIII YQYMDDLYVGSDLEIGQHRAKVEELRAHLLSWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPDKEXWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDIVPLTEEAE LELAENREILKDPVHGVYYDPSKDLIAEIQKQGQ |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10IV, I13V, G16E, K20R, E35D, M36I, P39PS, R41K, K45KR, R57K, L63V, H69K, I85IV, L89M |
| >ESH253| codons 1-99 PQITLWQRPIVTVKIEGQLREALLDTGADDTVLEDINLSGKWKPRMIGGIGGFIKVKQYD QIVIEICGKKAIGTVLVGPTPVNIVGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Eshleman, SH | Characterization of nevirapine resistance mutations in women with subtype A vs. D HIV-1 6-8 weeks after single-dose nevirapine. | JAIDS, 2004 |