Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1581 | CA4511 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 30 |
| 2 | SQV | 21 |
| 3 | 3TC+ SQV | 8 |
| 4 | 3TC+ D4T+ SQV | 12 |
| 5 | 3TC+ DDI+ D4T+ SQV | 13 |
| 6 | 3TC+ DDI+ IDV+ D4T+ SQV | 28 |
| 7 | 3TC+ DDI+ SQV+ NVP+ IDV | 12 |
| 8 | 3TC+ NFV+ SQV | 34 |
| 9 | DDI+ SQV+ RTV | 11 |
| 10 | DDI+ ABC+ EFV+ SQV+ RTV | 14 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V | L24I, T74P | L10I, K43R, D60E, I62V, L63Q, I64V, H69R, A71V, V77I, I93L |
| >CA4511| codons 1-99 PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEEMNLPGRWRPKIIGGIGGFIKVRQYE QVQVEICGRKVIGPVLIGPTPVNVIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74I, V75M, M184V, T215Y | K103N | V108I | K64R, K122E, G196E, H221HY, D237N, A272P, K277R, T286A, E297K | N265NT |
| >CA4512| codons 1-301 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIRKKDSTKWRKIMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGFYTPDKKYQKEPPFLWMGYELHPNKWT VQPIVLPEKDSWTVNDIQKLVGKLTWASQIYPGIKVRQLCKLLRGAKALTEVIPLTKEAE L |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |