Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1435 | CA4508 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 20 |
| 2 | AZT+D4T | 29 |
| 3 | 3TC+D4T | 12 |
| 4 | 3TC+AZT+D4T+IDV | 28 |
| 5 | DDC+RTV+SQV | 29 |
| 6 | AZT+DDI+NFV | 28 |
| 7 | ABC+EFV+RTV+SQV | 22 |
| 8 | 3TC+ABC+EFV+NFV | 10 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, L74V, M184V, T215F | K219Q | Y181C | E6EK, V35K, V60I, K104N, V118I, K122E, I135T, S162D, G190X, F214L, A272P, K287KE | K281KE |
| >CA4508| codons 1-289 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALKEICTELEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKNSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDIVI CQYVDDLYVXSDLEIGQHRTKIEELRQHLLRWGLFTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCELLRGTEAL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, V82A, L90M | L10V, T12S, L19Q, M36ML, N37S, P39PQ, I62V, L63P, A71V |
| >CA4507| codons 1-99 PQITLWQRPVVSIKIGGQQKEALLDTGADDTILEELSLQGRWKPKIIGGIGGFIKVRQYD QVPIEICGHKVIGTVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |