<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
BLF_Pat35 BR03SP71 Brazil 2003 HIV1 F Plasma None

Treatment History
Order Regimen Weeks
1 DDC+ AZT 56
2 IDV+ D4T+ 3TC 95
3 NFV+ 3TC+ AZT 174

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, M184V, L210W, T215Y       E6A, K20R, V35T, T39Q, E44D, K122E, I135V, S162C, E169D, K173A, Q174K, I178L, Q207E, R211K, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, E297A  
>BR03SP71| codons 1-335
PISPIATVPVKLKPGMDGPRVKQWPLTEEKIKALTEICQELEKDGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRAKNPDLVI
YQYVDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVTLTAEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQG

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, L90M   L10V, I13V, I15V, K20T, E35D, M36I, N37T, R41K, R57K, Q61N, A71T, T74S, L89I  
>BR03SP71| codons 1-99
PQITLWQRPVVTVKVGGQLTEALLDTGADDTVLEDITLPGKWKPKMIGGIGGFVKVKQYD
NILIEICGHKTIGSVLVGPTPVNIIGRNIMTQIGCTLNF

References
Author Title Citation
Rodrigues, R Prevalence of ARV resistance mutations and impact of genotyping test in HIV patients with advance disease in Sao Paulo, Brazil. J Clin Virol, 2005