Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| BLF_Pat22 | BR03SP87 | Brazil | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT | 95 |
| 2 | RTV+ D4T+ 3TC | 91 |
| 3 | NFV+ 3TC+ AZT+ NVP | 43 |
| 4 | APV+ D4T+ DDI | 47 |
| 5 | APV+ RTV+ 3TC+ AZT | 36 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L24I, Q58E | L10I, I15V, K20R, E35D, M36I, R41K, K55R, R57K, D60E, Q61N, L63P, T74A, L89M |
| >BR03SP87| codons 1-99 PQITLWQRPIVTIKVGGQLREALIDTGADDTVLEDINLPGKWKPKLIGGIGGFVRVKEYE NIPIEICGHKAIGAVLVGPTPANIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | K101E, Y181CG, G190GA | E6N, K20R, V35T, T39K, K43E, E44D, V118I, K122E, I135V, S162Y, K173A, Q174K, V179VI, Q207E, R211K, L228H, Q242X, V245Q, A272P, K275Q, V276T, T286A, A288T, E291D, V292I, I293V, P294S, E297T |
| >BR03SP87| codons 1-335 PISPINTVPVKLKPGMDGPRVKQWPLTEEKIKALTEICKELEEDGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRAKNPDIII CQYVDDLYVASDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFHWMGYELHPDKWT VXPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIQTKQLCKLLRGAKTLTDIVSLTTEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQG |
References
| Author | Title | Citation |
| Rodrigues, R | Prevalence of ARV resistance mutations and impact of genotyping test in HIV patients with advance disease in Sao Paulo, Brazil. | J Clin Virol, 2005 |