Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| BLF_Pat17 | BR02SP88 | Brazil | 2002 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 30 |
| 2 | DDI+ AZT | 21 |
| 3 | SQV+ DDI+ AZT | 17 |
| 4 | IDV+ 3TC+ AZT | 30 |
| 5 | RTV+ SQV+ D4T+ 3TC | 21 |
| 6 | NFV+ DDI+ AZT+ NVP | 47 |
| 7 | IDV+ RTV+ D4T+ 3TC+ DLV | 74 |
| 8 | 3TC+ AZT+ NVP+ LPV | 96 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, M184V, T215Y | V75S, K219E | K103N | A98G, V108I | E6K, K20R, K32R, V35T, T39A, E44D, V118I, K122E, S162Y, E169D, K173A, Q174K, T200A, E203K, Q207E, H208Y, W212WL, K223E, L228H, Q242H, V245Q, E248D, A272P, K277R, L283I, T286A, E291D, V292I, I293V, E297T, D324E, Q334E |
| >BR02SP88| codons 1-335 PISPIKTVPVKLKPGMDGPRVKQWPLTEEKIRALTEICAELEKDGKISKIGPENPYNTPV FAIKKKNSTRWRKISDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILDPFRAKNPDIVI YQYVDDLYVGSDLEIGQHRAKIKELREYLLRLGFYTPDEKHQEEPPFHWMGYELHPDKWT VHPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGAKALTDIVPLTTEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGEG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I50V, I54V, V82T, L90M | K43T | L10I, T12N, I15V, L19P, K20R, E21Q, E35D, M36I, N37D, K55R, R57K, Q61N, L63P, A71V, I72V, I85V, L89I, Q92K |
| >BR02SP88| codons 1-99 PQITLWQRPIVNIKVGGQPRQALLDTGADDTVLEDIDLPGRWTPKLIGGVGGFVRVKQYD NIPIEICGHKVVGTVLVGPTPTNIVGRNIMTKIGCTLNF |
References
| Author | Title | Citation |
| Rodrigues, R | Prevalence of ARV resistance mutations and impact of genotyping test in HIV patients with advance disease in Sao Paulo, Brazil. | J Clin Virol, 2005 |