<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
881214 881214 Spain 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT+ DDI 65
2 AZT+ DDI+ SQV 56
3 AZT+ 3TC+ IDV 13
4 D4T+ RTV+ SQV 21
5 NVP+ NFV 52
6 DDI+ D4T+ IDV 41

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74I, L210W, T215Y K219N Y181C   K32Q, V35E, T39A, E40F, K43E, V118I, K122E, I135R, H208Y, R211K, K223E, L228H  
>881214| codons 1-253
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIQALEEICAFLEEEGKISKIGPENPYNTPV
FAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSRNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
CQYMDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTPDNKHQEEPPFHWMGYELHPDKWT
VQPIVLPEKDSWT

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
L90M G73T L10V, T12I, I15V, G16A, K20M, E35G, M36I, R41K, I62V, L63P, H69R, K70T  
>881214| codons 1-99
PQITLWQRPVVIIKVAGQLMEALLDTGADDTVLEGINLPGKWKPKMIGGIGGFIKVRQYD
QVPIEICGRTAITTVLVGPTPVNIIGRNLMTQIGCTLNF

References
Author Title Citation
Tural, C Clinical utility of HIV-1 genotyping and expert advice: the Havana trial. AIDS, 2002
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005