<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
880906 880906 Spain 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 38
2 AZT+ DDI 58
3 AZT+ DDI+ SQV 45
4 D4T+ 3TC+ IDV 44
5 DDI+ D4T+ NVP+ NFV 49

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I84V, L90M T74P L10I, I13V, I15V, K20M, M36I, D60E, I62V, L63P, A71I, I93L R87S
>880906| codons 1-99
PQITLWQRPIVTVKVGGQLMEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFIKVRQYE
QVPIEICGHKIIGPVLVGPTPVNVIGSNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, L210W, T215Y   K103N, Y181C   K20R, T39S, E44D, S48T, V60I, T69E, A98S, K102Q, V118I, K122E, D123S, I135T, R211K  
>880906| codons 1-253
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICSELEKDGKITKIGPENPYNTPI
FAIKKKNSEKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLKQNKSVTVLDVGDAYFSIPL
DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
CQYMDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWT

References
Author Title Citation
Tural, C Clinical utility of HIV-1 genotyping and expert advice: the Havana trial. AIDS, 2002
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005