Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 880509 | 880509 | Spain | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 78 |
| 2 | DDI | 30 |
| 3 | AZT+ DDI | 25 |
| 4 | AZT+ DDC | 82 |
| 5 | AZT+ DDC+ SQV | 39 |
| 6 | DDC+ D4T+ SQV | 8 |
| 7 | D4T+ 3TC+ IDV | 82 |
| 8 | D4T+ NVP+ NFV | 8 |
| 9 | D4T+ IDV+ NFV | 67 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L210W, T215Y | K103N, Y181C | K49R, I50V, K122E, I135T, S162C, L228H, P243S |
| >880509| codons 1-250 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISRVGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI CQYMDDLYVGSDLEIGQHRTKIEELRQHLWRWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQSIVLPEKD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | L10I, L19I, L63P, I64L, A71I, I72K, V77I, V82I, I93M, C95F | R87S |
| >880509| codons 1-99 PQITLWQRPIVTIKIGGQIKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYD QIPLEICGHKIKGTVLIGPTPINIIGSNLMTQMGFTLNF |
References
| Author | Title | Citation |
| Tural, C | Clinical utility of HIV-1 genotyping and expert advice: the Havana trial. | AIDS, 2002 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |