Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 880423 | 880423 | Spain | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 161 |
| 2 | AZT+ DDI | 56 |
| 3 | AZT+ DDC | 76 |
| 4 | AZT+ 3TC | 94 |
| 5 | D4T+ 3TC+ IDV | 40 |
| 6 | D4T+ NVP+ NFV | 37 |
| 7 | D4T+ NVP+ SQV+ NFV | 43 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82F, L90M | L23I | L10I, E35D, N37D, R41K, F53Y, L63P, A71T, I72V, V77I, Q92R, I93L |
| >880423| codons 1-99 PQITLWQRPIVTIKIGGQLKEAILDTGADDTVLEDMDLPGKWKPKIIGGIGGYVKVRQYD QIPIEICGHKTVGTVLIGPTPFNIIGRNLMTRLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215Y | Y181C | V35I, K43Q, A98S, D121Y, K122E, A158S, K166R, D177E, R211K |
| >880423| codons 1-233 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEQEGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQSSMTRILEPFRKQNPEIVI CQYMDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYE |
References
| Author | Title | Citation |
| Tural, C | Clinical utility of HIV-1 genotyping and expert advice: the Havana trial. | AIDS, 2002 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |