Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1555 | CA4444 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 156 |
| 2 | DDI | 52 |
| 3 | NRTI | 47 |
| 4 | 3TC+AZT | 13 |
| 5 | 3TC+AZT+RTV | 8 |
| 6 | 3TC+AZT+IDV | 30 |
| 7 | 3TC+D4T+IDV | 80 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70KR, M184V, T215Y | K219N | K20R, V60I, A98S, I135T, K166R, E169D, G196E, T200A, R211RS, V245M |
| >CA4444| codons 1-257 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILDPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRAKIEELRQHLLSWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIMLPEKDSWTVNDI |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A | L24I | L10I, T12A, R41K, L63P, A71V, V77I, I93L |
| >CA4443| codons 1-99 PQITLWQRPIVAIKIGGQLKEALIDTGADDTVLEEMNLPGKWKPKIIGGIGGFVKVRQYD QIPIEICGHKVIGTVLIGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |