<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
880240 880240 Spain 2000 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT+ 3TC 4
2 D4T+ 3TC+ IDV 52
3 DDI+ D4T+ NVP 27
4 DDI+ D4T+ EFV 40

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I L10F K14R, Q18H, N37D, R41K, L63P, A71T, I72T, Q92R, I93L  
>880240| codons 1-99
PQITLWQRPFVTIRIGGHLKEALLDTGADDTVLEEMDLPGKWKPKIIGGIGGFIKVRQYD
QIPIEICGHKTTGTVLVGPTPVNIIGRNLLTRLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L210W, T215Y   K103N, Y181C   K43E, K49R, W88C, V118I, K122E, D123E, I135M, S162D, D177E, G196E, R211K, H221Y  
>880240| codons 1-249
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEEGKISRIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFCEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL
DEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPEIVI
CQYMDDLYVGSDLEIEQHRTKIEELRQHLWKWGFYTPDKKYQKEPPFLWMGYELHPDKWT
VQPIVLPEK

References
Author Title Citation
Tural, C Clinical utility of HIV-1 genotyping and expert advice: the Havana trial. AIDS, 2002
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005