Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1554 | CA4442 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T | 61 |
| 2 | AZT | 30 |
| 3 | 3TC+AZT+DDI | 13 |
| 4 | DDI+IDV+RTV | 31 |
| 5 | DDI+NVP+RTV | 30 |
| 6 | DDC+DLV+RTV+SQV | 45 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T215Y | K219Q | K103N, Y188L | V35I, R83K, K102Q, K122E, K166R, I178L, A272P, K277R, L283I, I293V, E297K |
| >CA4442| codons 1-302 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKQNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDLVI YQYMDDLLVGSDLEIGQHRTKIEELRQHLLRWGFYTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKALTEVVPLTKEAE LE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I54IV, I84V, L90M | K20KR, E35D, M36I, N37T, D60E, Q61E, L63P, I64V, A71AV |
| >CA4441| codons 1-99 PQITLWQRPLVTIKIGGQLREALLDTGADDTVLEDITLPGRWKPKIIGGIGGFVKVRQYE EIPVEICGHKVIGTVLVGPTPVNVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |