<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
880219 880219 Spain 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 208
2 AZT+ DDC 26
3 AZT+ DDI 26
4 DDI+ D4T 25
5 D4T+ 3TC+ IDV 17
6 D4T+ 3TC+ SQV 34
7 DDI+ D4T+ NFV 70

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
D30N   I13V, K20T, E35D, M36I, K45Q, I64V  
>880219| codons 1-99
PQITLWQRPLVTVKIGGQLTEALLDTGADNTVLEDINLPGRWKPQMIGGIGGFIKVRQYD
QILVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, Q151M, T215F F116Y, K219Q     K20R, V60I, T69N, V90I, S162H, R172K, H208Y, R211K  
>880219| codons 1-250
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI
FAIKKKNSNRWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYYSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQHSMTKILEPFKKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQYLLKWGFFTPDQKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKD

References
Author Title Citation
Tural, C Clinical utility of HIV-1 genotyping and expert advice: the Havana trial. AIDS, 2002
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005