Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 368428 | 368428 | Spain | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | DDI | 21 |
| 3 | D4T+ 3TC | 30 |
| 4 | D4T+ 3TC+ IDV | 73 |
| 5 | D4T+ 3TC+ SQV | 30 |
| 6 | D4T+ 3TC+ RTV+ SQV | 47 |
| 7 | D4T+ 3TC+ IDV | 45 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | T74P | L10I, K14R, E35D, N37D, D60E, I62V, L63P, A71I, V77I, I93L |
| >368428| codons 1-99 PQITLWQRPIVTIRIGGQLKEALLDTGADDTVLEDMDLPGRWKPKIIGGIGGFIKVRQYE QVPIEICGHKIIGPVLIGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, T215Y | K122E, D123N, I142V, Q174K, Q197K, T200E, E203K, Q207E, R211K |
| >368428| codons 1-260 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDIVI YQYVDDLYVGSDLEIGKHREKIKELREHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKL |
References
| Author | Title | Citation |
| Tural, C | Clinical utility of HIV-1 genotyping and expert advice: the Havana trial. | AIDS, 2002 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |