Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1553 | CA4439 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 108 |
| 2 | 3TC+AZT+IDV | 21 |
| 3 | D4T+RTV+SQV | 52 |
| 4 | D4T+DLV+NFV | 21 |
| 5 | 3TC+D4T+NFV | 28 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | F53L, G73S | L10I, I13V, K20R, E35D, M36I, R41K, I62V, L63P, A71V, V77I |
| >CA4439| codons 10-99 IVTVKIGGQLREALLDTGADDTVLEDINLPGKWKPKIIGGIGGLIKVRQYDQVPIEICGH KVISTVLIGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | V75L, K219N | L100I, K103N | K20R, E28K, K32E, V35L, T39K, K43E, E44D, V118I, K122E, Q197E, E203K, H208Y, R211K, K223Q, I293V, E297A |
| >CA4440| codons 1-303 PISPIETVPVKLKPGMDGPRVKQWPLTKEKIEALLEICKELEEDGKISKIGPENPYNTPV FAIKKKNSTKWRKLLDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGEHRTKIKELRQYLWKWGFYTPDNKHQQEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTAEAE LEL |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |