Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 272545 | 272545 | Spain | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | AZT+ DDI | 52 |
| 3 | AZT | 169 |
| 4 | AZT+ 3TC | 13 |
| 5 | AZT+ 3TC+ IDV | 4 |
| 6 | AZT+ 3TC+ RTV | 13 |
| 7 | AZT+ 3TC+ RTV+ SQV | 25 |
| 8 | D4T+ 3TC+ RTV+ SQV | 82 |
| 9 | DDI+ 3TC+ ABC+ EFV+ SQV+ NFV | 12 |
| 10 | DDI+ 3TC+ ABC+ EFV+ NFV | 30 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, I84V, L90M | L10V, K55R, R57K, D60E, Q61E, L63P, A71V, I72V, V77I |
| >272545| codons 1-99 PQITLWQRPVVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVRVKQYE EIPIEICGHKVVGTVLIGPTPANVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219N | K103N, G190S | E44D, V118I, K122E, V179I, G196E, T200A, I202V, E203V, Q207E, R211K, D250E |
| >272545| codons 1-250 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYVDDLYVSSDLEIEQHRAKVVELREHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIVLPEKE |
References
| Author | Title | Citation |
| Tural, C | Clinical utility of HIV-1 genotyping and expert advice: the Havana trial. | AIDS, 2002 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |