Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 193544 | 193544 | Spain | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDC | 139 |
| 2 | AZT+ DDC+ SQV | 30 |
| 3 | D4T+ 3TC+ RTV | 64 |
| 4 | DDI+ D4T+ RTV+ SQV | 47 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | F53L, G73C | L10I, I15V, G16E, K20M, M36I, N37D, L63S, A71V, I72R |
| >193544| codons 1-99 PQITLWQRPIVTIKVEGQLMEALLDTGADDTVLEEIDLPGRWKPKMIGGIGGLVKVRQYD QISIEICGHKVRCTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215F | K219Q | T39N, V60I, K104R, V118I, K122E, D123E, I135T, I195L, F214L, K223Q, L228H |
| >193544| codons 1-246 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICNEMEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKRSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLELGQHRTKIEELRQHLLRWGLFTPDQKHQQEPPFHWMGYELHPDKWT VQPIVL |
References
| Author | Title | Citation |
| Tural, C | Clinical utility of HIV-1 genotyping and expert advice: the Havana trial. | AIDS, 2002 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |