<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
193544 193544 Spain 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT+ DDC 139
2 AZT+ DDC+ SQV 30
3 D4T+ 3TC+ RTV 64
4 DDI+ D4T+ RTV+ SQV 47

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82A, L90M F53L, G73C L10I, I15V, G16E, K20M, M36I, N37D, L63S, A71V, I72R  
>193544| codons 1-99
PQITLWQRPIVTIKVEGQLMEALLDTGADDTVLEEIDLPGRWKPKMIGGIGGLVKVRQYD
QISIEICGHKVRCTVLVGPTPANIIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70R, T215F K219Q     T39N, V60I, K104R, V118I, K122E, D123E, I135T, I195L, F214L, K223Q, L228H  
>193544| codons 1-246
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICNEMEKEGKISKIGPENPYNTPI
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKRSVTVLDVGDAYFSIPL
DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLELGQHRTKIEELRQHLLRWGLFTPDQKHQQEPPFHWMGYELHPDKWT
VQPIVL

References
Author Title Citation
Tural, C Clinical utility of HIV-1 genotyping and expert advice: the Havana trial. AIDS, 2002
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005