<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
154695 154695 Spain 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 147
2 AZT+ 3TC 65
3 AZT+ 3TC+ RTV 17
4 D4T+ 3TC+ IDV 21
5 AZT+ DDC 17
6 3TC+ NVP+ SQV+ IDV 47
7 DDI+ 3TC+ NVP+ SQV+ NFV 13
8 DDI+ D4T+ 3TC+ NVP+ RTV+ SQV+ NFV 77

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82T, I84V, L90M   L10I, R41K, I62V, L63P, A71V, Q92R, I93L, C95F  
>154695| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGFVKVRQYD
QVPIEICGHKVIGTVLVGPTPTNVIGRNLMTRLGFTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74I, M184V, T215F K219Q K103N, Y181C   K20R, K43N, T69N, I202V, R211S, D218E  
>154695| codons 1-250
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELENEGKISKIGPENPYNTPV
FAIKKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
CQYVDDLYVGSDLEIGQHRTKVEELRQHLLSWGFFTPEQKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKD

References
Author Title Citation
Tural, C Clinical utility of HIV-1 genotyping and expert advice: the Havana trial. AIDS, 2002
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005