<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
59314 59314 Spain 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 34
2 None 190
3 AZT+ DDC 109
4 DDI+ D4T+ SQV 109

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, M184V, L210W, T215Y       T39A, E44D, V118I, I142V, Q174K, I178M, G196E, T200I, E203G, Q207E, H208Y, R211N, E248D K43H
>59314| codons 1-250
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEHDGKISKIGPENPYNTPV
FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDMVI
YQYVDDLYVGSDLEIEQHRIKIGELREYLWNWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPDKD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
L90M   L10I, K20T, E35D, M36I, N37D, L63P, A71T, I72V, T74S, V77I  
>59314| codons 1-99
PQITLWQRPIVTIKIGGQLTEALLDTGADDTVLEDIDLPGRWKPKMIGGIGGFIKVRQYD
QIPIEICGHKTVGSVLIGPTPVNIIGRNLMTQIGCTLNF

References
Author Title Citation
Tural, C Clinical utility of HIV-1 genotyping and expert advice: the Havana trial. AIDS, 2002
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005