Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 30528 | 30528 | Spain | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 104 |
| 2 | DDI | 65 |
| 3 | AZT+ DDI | 61 |
| 4 | AZT+ DDI | 3 |
| 5 | AZT+ DDI+ RTV | 47 |
| 6 | AZT+ DDI+ 3TC+ RTV | 26 |
| 7 | AZT+ DDI+ 3TC+ RTV+ SQV | 21 |
| 8 | D4T+ 3TC+ RTV+ SQV | 43 |
| 9 | D4T+ 3TC+ ABC+ NVP+ SQV+ NFV | 76 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | K103N, Y181C | V35I, R83K, A98S, I135T, I142V, S162C, R211K, H221C, L228Q, Q242H, D250E |
| >30528| codons 1-250 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKKTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI CQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKCQKEPPFQWMGYELHPDKWT VHPIVLPEKE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48T, I54V, V82A | L24I | L10I, K20R, E35D, M36I, N37D, R41K, I64V, A71V, I93L |
| >30528| codons 1-99 PQITLWQRPIVTIKIGGQLREALIDTGADDTVLEDIDLPGKWKPKLITGIGGFVKVRQYD QILVEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Tural, C | Clinical utility of HIV-1 genotyping and expert advice: the Havana trial. | AIDS, 2002 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |