<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
30528 30528 Spain 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 104
2 DDI 65
3 AZT+ DDI 61
4 AZT+ DDI 3
5 AZT+ DDI+ RTV 47
6 AZT+ DDI+ 3TC+ RTV 26
7 AZT+ DDI+ 3TC+ RTV+ SQV 21
8 D4T+ 3TC+ RTV+ SQV 43
9 D4T+ 3TC+ ABC+ NVP+ SQV+ NFV 76

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, M184V, L210W, T215Y   K103N, Y181C   V35I, R83K, A98S, I135T, I142V, S162C, R211K, H221C, L228Q, Q242H, D250E  
>30528| codons 1-250
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKVVDFRELNKKTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI
CQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKCQKEPPFQWMGYELHPDKWT
VHPIVLPEKE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, G48T, I54V, V82A L24I L10I, K20R, E35D, M36I, N37D, R41K, I64V, A71V, I93L  
>30528| codons 1-99
PQITLWQRPIVTIKIGGQLREALIDTGADDTVLEDIDLPGKWKPKLITGIGGFVKVRQYD
QILVEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF

References
Author Title Citation
Tural, C Clinical utility of HIV-1 genotyping and expert advice: the Havana trial. AIDS, 2002
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005