Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1549 | CA4431 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 187 |
| 2 | 3TC+AZT | 67 |
| 3 | 3TC+D4T+IDV | 39 |
| 4 | DDC+DLV+NFV+SQV | 22 |
| 5 | 3TC+D4T+NFV+SQV | 29 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L24I, L33LI, K43T, G73S | L10I, T12P, I15V, K20R, M36I, Q61DN, L63P, A71V |
| >CA4431| codons 1-99 PQITLWQRPIVPIKVGGQLREALIDTGADDTVIEEINLPGRWTPKLIGGIGGFVKVRQYD DIPIEICGHKVISTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, M184V, L210W, T215Y | K219R | K43E, E44A, A98AS, V111I, V118I, K122KE, I135T, E203K, H208Y, R211K, K223Q, L228R, I257L, A272P, K277R, T286A, I293V |
| >CA4432| codons 1-297 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPV FAIKKKDSDKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDIGDAYFSIPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIKELRQYLWKWGFYTPDRKHQQEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDLQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVVPLTE |
References
| Author | Title | Citation |
| Kantor, R | Evolution of primary protease inhibitor resistance mutations during protease inhibitor salvage therapy. | AAC, 2002 |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |