Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1548 | CA4429 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 117 |
| 2 | AZT+ DDC | 108 |
| 3 | DDI | 95 |
| 4 | D4T | 30 |
| 5 | 3TC+ AZT | 39 |
| 6 | 3TC+ AZT+ IDV | 21 |
| 7 | 3TC+ D4T+ IDV | 12 |
| 8 | 3TC+ D4T+ NFV+ NVP | 21 |
| 9 | 3TC+ D4T+ NFV+ SQV | 33 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A | L24I, K43T, F53FL | L10I, E35D, M36I, I62V, L63P, I64V |
| >CA4429| codons 1-99 PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEDINLPGRWTPKIIGGIGGLVKVRQYD QVPVEICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, M184V, T215Y | K219E | K103N | K20R, V60I, D123E, S162C, I178M, V179I, T200A, E203D, D218E, L228H, I293V |
| >CA4430| codons 1-300 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDMII YQYVDDLYVGSDLEIGQHRAKIDELRQHLLRWGFYTPEEKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |