<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
UK4758 UK4758 U.K. 2003 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 3TC+ D4T+ EFV 69
2 None 26
3 EFV+ 3TC+ AZT 11

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V   K103N P225H E6EK, K20KR, V21I, V35T, E36A, T39E, E40D, S48T, E53ED, W88C, V90VI, D121Y, K122E, S162Y, K173A, D177E, I195L, T200A, Q207D, R211K  
>UK4758| codons 1-232
PISPIKTVPVKLKPGMDGPRIKQWPLTEEKIKALTAICEDMEKEGKITKIGPDNPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFCEIQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRAQNPEIVI
YQYVDDLYVGSDLELGQHRAKIEELRDHLLKWGFTTPDKKHQKEHPFLWMGY

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12TS, I15V, L19I, M36I, N37S, R41K, H69K, L89M, I93L  
>UK4758| codons 1-99
PQITLWQRPLVSIKVGGQIKEALLDTGADDTVLEEISLPGKWKPKMIGGIGGFIKVRQYD
QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005