Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1544 | CA4416 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+D4T+NFV | 35 |
| 2 | DDI+NVP+RTV+SQV | 29 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, I84IV, L90M | N88D | L10R, T12P, K14R, L63P, A71T, I72T, V77I, I93L |
| >CA4416| codons 1-99 PQITLWQRPRVPIRIGGQLKEALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKTTGTVLIGPTPVNVIGRDLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184MV | Y181I | V35T, K122Q, D177E, T200I, Q207E, L228R, V245E, K277R, I293V | K275KI |
| >CA4417| codons 1-298 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DQDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI IQYVDDLYVGSDLEIGQHRIKIEELREHLLRWGFTTPDKKHQKEPPFRWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIIVRQLCKLLRGTKALTEVVPLTEE |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |