Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1531 | CA4385 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 208 |
| 2 | AZT+ DDC | 200 |
| 3 | AZT+ DDI | 8 |
| 4 | 3TC+ AZT | 8 |
| 5 | 3TC+ AZT+ IDV | 48 |
| 6 | 3TC+ DDC+ RTV+ SQV | 47 |
| 7 | 3TC+ D4T+ RTV+ SQV | 16 |
| 8 | 3TC+ AZT+ RTV+ SQV | 17 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, V82VA, I84V, L90M | F53FL, G73GS | L10I, M36MI, I62V, L63P, A71V, I72V |
| >CA4385| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEINLPGRWKPKIIGGIGGLIKVRQYD QVPIEICGHKVVSTVLVGPTPANVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, D67N, K70R, M184V, T215F | K219Q | S48T, T69N, K122E, G196E, H208Y, D218E, V245M, A272P, A288ST, E297K |
| >CA4386| codons 1-302 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKITKIGPENPYNTPV FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQYLLRWGFFTPEQKHQKEPPFLWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKSLTEVIPLTKEAE LE |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |