Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1274 | CA4371 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 187 |
| 2 | AZT+DDC+SQV | 100 |
| 3 | 3TC+DDI | 20 |
| 4 | 3TC+D4T+IDV | 23 |
| 5 | DDC+RTV+SQV | 20 |
| 6 | AZT+DLV+NFV+SQV | 18 |
| 7 | 3TC+DDI+IDV | 23 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | Q58E, G73S | L10I, I15V, K20I, M36I, I62V, L63P |
| >CA4371| codons 1-99 PQITLWQRPIVTIKVGGQLIEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVREYD QVPIEICGHKAISTVLVGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70G, M184V, T215F | K219Q | K103KN | K102Q, K122E, I135V, D177E, G196E, I202V, E248ED, A272G, A288S, I293V |
| >CA4372| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTGWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIEQHRTKVEELRQHLLRWGFFTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPDKDSWTVNDIQKLVGKLNWASQIYGGIKVKQLCKLLRGTKSLTEVVPLTEEAE LEL |
References
| Author | Title | Citation |
| Shulman, NS | Efavirenz- and adefovir dipivoxil-based salvage therapy in highly treatment-experienced patients: Clinical and genotypic predictors of virologic response. | JAIDS, 2000 |
| Kantor, R | Evolution of primary protease inhibitor resistance mutations during protease inhibitor salvage therapy. | AAC, 2002 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | Distribution of human immunodeficiency virus type 1 protease and reverse transcriptase mutation patterns in 4,183 persons undergoing genotypic resistance testing. | AAC, 2004 |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |