Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| M64940 | M64940 | U.K. | 2003 | HIV1 | G | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 104 |
| 2 | IDV+ D4T+ 3TC | 134 |
| 3 | NFV+ NVP+ DDI+ D4T | 61 |
| 4 | DDI+ ABC+ 3TC | 167 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48A, I54V, V82S, L90M | L89V | L10I, I13A, K14R, K20I, M36I, N37D, R41K, L63P, H69K, K70KR, A71V |
| >M64940| codons 1-99 PQITLWQRPIVTARIGGQLIEALLDTGADDTVLEEIDLPGKWKPKMIAGIGGFVKVRQYD QIPIEICGKRVIGTVLVGPTPSNIIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, L74V, M184V | K219Q | Y181C, G190A | A98G | E6S, K11T, K20R, V35T, V60I, K122E, D123S, K173T, D177E, G196R, T200A, I202IV, Q207E, R211K, F214L, L228H, V245Q, E248D, D250E, A272P, E291D, V292VI, I293V, E297AT, D324E | I309IM, Q332QE |
| >M64940| codons 1-335 PISPISTVPVTLKPGMDGPRVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKVVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTQNPEIVI CQYVDDLYVASDLEIRQHRAKVEELREHLLKWGLTTPDQKHQKEPPFHWMGYELHPDKWT VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDIVPLTTEAE LELAENREMLKEPVHGVYYDPSKELIAEIQKEGQG |
References
| Author | Title | Citation |
| Weber, J | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |