<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA1463 CA4338 U.S. 1998 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 17
2 DDI 35
3 Unknown NA
4 3TC+DDI+SQV 78
5 3TC+D4T+IDV 8
6 3TC+D4T+RTV 4
7 D4T+DDI+NFV NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I84V, L90M Q58E, G73ST L10I, I15IV, G17D, L63P, I64IV, A71V, V77IT, P79X, I93L  
>CA4338| codons 1-99
PQITLWQRPIVTIKVGDQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVREYD
QIPVEICGHKVISTVLIGXTPVNVIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K70G, Q151M, M184V A62V Y181C   V35I, S68N, I135T, S162SG, D177E, I178M, G196E, E203G, R211K, F214L, V245M, A272P, I293V Q258QH, V261VL
>CA4339| codons 1-293
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV
FVIKKKDNTGWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSPAIFQGSMTKILEPFRKQNPEMVI
CQYVDDLYVGSDLEIEQHRTKIGELRQHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIMLPEKDSWTVNDIHKLLGKLNWASQIYPGIKVKQLCKLLRGTKALTEVV

References
Author Title Citation
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005