Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1463 | CA4338 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 17 |
| 2 | DDI | 35 |
| 3 | Unknown | NA |
| 4 | 3TC+DDI+SQV | 78 |
| 5 | 3TC+D4T+IDV | 8 |
| 6 | 3TC+D4T+RTV | 4 |
| 7 | D4T+DDI+NFV | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | Q58E, G73ST | L10I, I15IV, G17D, L63P, I64IV, A71V, V77IT, P79X, I93L |
| >CA4338| codons 1-99 PQITLWQRPIVTIKVGDQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVREYD QIPVEICGHKVISTVLIGXTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70G, Q151M, M184V | A62V | Y181C | V35I, S68N, I135T, S162SG, D177E, I178M, G196E, E203G, R211K, F214L, V245M, A272P, I293V | Q258QH, V261VL |
| >CA4339| codons 1-293 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FVIKKKDNTGWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSPAIFQGSMTKILEPFRKQNPEMVI CQYVDDLYVGSDLEIEQHRTKIGELRQHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIMLPEKDSWTVNDIHKLLGKLNWASQIYPGIKVKQLCKLLRGTKALTEVV |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |