Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| M36781 | M36781-2 | U.K. | 2003 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T+ DDI+ NVP | 8 |
| 2 | Unknown | 33 |
| 3 | 3TC+ EFV+ AZT | 23 |
| 4 | AZT+ 3TC+ NVP | 31 |
| 5 | None | 17 |
| 6 | NVP+ AZT+ 3TC | 94 |
| 7 | DDI+ LPV+ TDF | 8 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, T215F | V75I | K103N | V35T, V90I, A98S, K122E, D123N, I132L, I135T, S162H, K173A, D177E, T200A, Q207A, R211N, V245M, K281R, E291D, I293V, P294T, E298G, E312N, S322A |
| >M36781-2| codons 1-334 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLIDFRELNKRTQDFWEIQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DENFRKYTAFTLPSTNNETPGIRYQYNVLPQGWKGSPAIFQHSMTKILEPFRAQNPEIVI YQYVDDLYVGSDLEIGQHRAKIEELRAHLLNWGFFTPDKKHQKEPPFLWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCRLLRGTKALTDVVTLTEGAE LELAENREILKNPVHGVYYDPAKDLIAEIQKQGQ |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13V, G16E, E35D, M36I, R41K, K45R, R57K, H69K, I72K, L89M |
| >M36781-2| codons 1-99 PQITLWQRPLVTVKIEGQLKEALLDTGADDTVLEDINLPGKWKPRMIGGIGGFIKVKQYD QILIEICGKKAKGTVLVGPTPVNIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Weber, J | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |