Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1512 | CA4330 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 173 |
| 2 | DDC | 26 |
| 3 | NRTI | 130 |
| 4 | 3TC+D4T+RTV | 8 |
| 5 | 3TC+D4T+IDV | 30 |
| 6 | 3TC+D4T+SQV | 12 |
| 7 | D4T+DDI+NFV | 43 |
| 8 | D4T+DDI+RTV+SQV | 17 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, T215F | K219Q | T39A, T139M, V179I, G196E, E224D, V245K | N136NI |
| >CA4330| codons 1-256 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSIINEMPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYMDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTPDQKHQKDPPFLWMGYELHPDKWT VQPIKLPEKDSWTVND |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82A, I84V | Q58E | L10I, I62V, L63A, A71V |
| >CA4329| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIVGIGGFVKVREYD QVAIEICGHKVIGTVLVGPTPANVIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |