Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1503 | CA4303 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 104 |
| 2 | DDC | 104 |
| 3 | NRTI | 173 |
| 4 | D4T | 30 |
| 5 | D4T+ DDI | 26 |
| 6 | SQV+ DDI+ D4T | 26 |
| 7 | IDV+ D4T+ 3TC | 17 |
| 8 | NVP+ D4T+ 3TC | 4 |
| 9 | NFV+ AZT+ 3TC | 52 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, K70R, M184V, T215Y | D67G | E36EQ, S68G, K102Q, K103R, K122E, I135V, S162C, G196E, I202IM |
| >CA4303| codons 1-249 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVQICTELEKEGKISKIGPENPYNTPV FAIKKKGGDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQRKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKMEELRQHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEK |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | N88ND | N37NS, K45KR, L63A, V77I |
| >CA4302| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEEMSLPGRWKPRMIGGIGGFIKVRQYD QIAIEICGHKAIGTVLIGPTPVNIIGRDLLTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |