Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA18424 | CA42995 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+D4T+IDV | 135 |
| 2 | 3TC+D4T+EFV | 85 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A | L10I, E35D, R41K, I62V, L63P, A71T, V77I, I93L |
| >CA42995| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDMNLPGKWKPKMIGGIGGFVKVRQYD QVPIEICGHKTIGTVLIGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | K103N | V108VI, P225PH | K11R, K20R, T139K, S162C, F171Y, G196E, T200A, Q207N, R211K, K277R, T286A, I293V, K311R, P313Q, G333E, Q334L | W252W* |
| >CA42996| codons 1-345 PISPIETVPVRLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL DKDFRKYTAFTIPSINNEKPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPYRKQNPDIVI YQYVDDLYVGSDLEIEQHRAKIEELRNHLLKWGFTTPDKKHQKEHPFLWMGYELHPDKWT VQPIVLPEKDS*TVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEVVPLTEEAE LELAENREILREQVHGVYYDPSKDLIAEIQKQELGQWTYQIYQEP |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |