Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA16485 | CA42779 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | Unknown | 52 |
| 2 | APV+D4T+DDI+LPV+TDF | 30 |
| 3 | 3TC+ABC+APV+D4T+DDI+RTV+TDF | 35 |
| 4 | None | 43 |
| 5 | 3TC+ABC+ATV+DDI+EFV+RTV+TDF | 8 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, I54V, I84V, L90M | L10F, L33F, N88D | I13V, I15V, E35D, M36I, N37E, I62V, L63P, L89F, I93L |
| >CA42779| codons 1-99 PQITLWQRPFVTVKVGGQLKEALLDTGADNTVFEDIELPGRWKPKMIGGIGGFVKVRQYD QVPIEICGHKAIGTVLVGPTPVNVIGRDFMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | K103N | V108I | K43N, E44D, V118I, K122E, I135T, S162C, I178M, G196E, T200A, E203D, Q207K, R211E, H221Y, A272P, K281R, E297K |
| >CA42780| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENDGKISKIGPENPYNTPV FAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDMVI YQYVDDLYVGSDLEIEQHRAKIDELRKHLWEWGFYTPDKKYQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVIPLTKEAE |
References
| Author | Title | Citation |
| Mitsuya, Y | N88D facilitates the co-occurrence of D30N and L90M and the development of multidrug resistance in HIV type 1 protease following nelfinavir treatment failure. | ARHR, 2006 |