<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA16485 CA42779 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 Unknown 52
2 APV+D4T+DDI+LPV+TDF 30
3 3TC+ABC+APV+D4T+DDI+RTV+TDF 35
4 None 43
5 3TC+ABC+ATV+DDI+EFV+RTV+TDF 8

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
D30N, I54V, I84V, L90M L10F, L33F, N88D I13V, I15V, E35D, M36I, N37E, I62V, L63P, L89F, I93L  
>CA42779| codons 1-99
PQITLWQRPFVTVKVGGQLKEALLDTGADNTVFEDIELPGRWKPKMIGGIGGFVKVRQYD
QVPIEICGHKAIGTVLVGPTPVNVIGRDFMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, V75M, M184V, L210W, T215Y   K103N V108I K43N, E44D, V118I, K122E, I135T, S162C, I178M, G196E, T200A, E203D, Q207K, R211E, H221Y, A272P, K281R, E297K  
>CA42780| codons 1-300
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENDGKISKIGPENPYNTPV
FAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDMVI
YQYVDDLYVGSDLEIEQHRAKIDELRKHLWEWGFYTPDKKYQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVIPLTKEAE

References
Author Title Citation
Mitsuya, Y N88D facilitates the co-occurrence of D30N and L90M and the development of multidrug resistance in HIV type 1 protease following nelfinavir treatment failure. ARHR, 2006